Arginase Enzyme Inhibition and with Subsequent Atheroprotection of Butanol Fraction of Rivea ornata in Lipid Emulsion Induced Atherosclerosis in Rats

Objectives: Atherosclerosis is caused by vascular inflammation and oxidative stress. Pro-atherogenic effect of hypercholesterolemia impairment nitric oxide generation due to activated arginase. The current study was wanted explore the atheroprotective polyphenolic fraction Rivea ornata using lipid emulsion induced atherosclerosis in rat model. Materials Methods: carried out studying atherogenic markers serum (lipid profiles, C-reactive protein), tissue (myeloperoxidase, arginase, hydroxyproline, peroxidation) factors (paraoxonase, oxide,) (thiol levels, endogenous antioxidants) after feeding rats with for 12 weeks. Results: Treatment rich butanol able correct imbalance antiatherogenic feeding. Butanol at dose 400 mg/kg significantly increases HDL, paraoxonase, oxide, thiol antioxidants decreases TG, TC, VLDL, LDL myeloperoxidase, peroxidation. And atheroprotection reflected histopathology studies also. Lipid associated foam cells formation inhibited fraction. Conclusion: This all presence gallic acid polyphenol responsible underlying mechanism atheroprotection.